This publication offers a selection of papers based on presentations at the AELFE-TAPP 2021 Conference, held in hybrid mode at Universitat Politècnica de Catalunya at Vilanova i la Geltrú (Barcelona, Spain) and online, from 7 to 9 July 2021. This conference, organized during the challenging time of the COVID-19 pandemic, had originally been scheduled in July 2020 and had to be postponed, and redesigned. The joint AELFE-TAPP 2021 Conference, co-siting the 19th Annual Conference of AELFE (Asociación Europea de Lenguas para Fines Específicos/European Association of Languages for Specific Purposes) and the 2nd TAPP (Trans-Atlantic and Pacific Project) Conference, brought together scholars from the fields of LSP (Languages for Specific Purposes) and virtual exchange. The common theme “Multilingual academic and professional communication in a networked world” aimed to inspire discussions that are situated at the crossroads between LSP and virtual exchange, which are pervasively present in current contexts where multilingual academic and professional communication takes place. In such increasingly networked workplace contexts and internationalized higher education institutions, professionals that possess a wide range of skills for digital communication are needed more than ever.